First-author conference presentation · 2021
Project Avalon: An Extended Machine Learning Framework for Spectronaut Dramatically Improves IDs for Short Gradient DIA Proteomics
Normand Overney, Oliver M. Bernhardt, Maximilian J. Helf, Tejas Gandhi, and Lukas Reiter
69th ASMS Conference on Mass Spectrometry and Allied Topics, Philadelphia
Evaluated eight classifiers and used genetic algorithms to tune a gradient-boosting model integrated into Spectronaut. Avalon improved peptide-precursor identifications by 20-40% on short-gradient dia-PASEF data while retaining comparable empirical false-discovery-rate performance.
